Sophic Starlight
Generative AI for Precision Medicine
Developed in partnership with Amazon Web Services (AWS) and Neo4j, Sophic Starlight empowers healthcare providers to unlock insights from complex genomic and clinical data—helping advance precision medicine with confidence.
What is Sophic Starlight?
Sophic Starlight is an AI-powered platform designed to assist pathologists, oncologists, physicians, and researchers by surfacing critical knowledge that is often hidden or difficult to access.
Rather than telling healthcare providers how to practice, Starlight makes valuable information easily available, enhancing decision-making and accelerating personalized care.
Starlight helps healthcare providers:
- Consolidate and interpret patient genomic, pharmacogenomic, and clinical data
- Build a comprehensive, living model of each patient
- Find clinical trials tailored to individual patients, with detailed information that empowers patients and providers to choose the most suitable option.
- Interact with trusted knowledge networks through a conversational AI interface
- Generate high-quality, editable reports to support clinical decisions
Starlight Capabilities
Holistic Patient Model
At the core of Starlight is the Holistic Patient Model—an evolving, integrated view of each patient.
The model brings together:
- Genomic and pharmacogenomic test results
- Disease states and phenotypes
- Medications
- Unstructured data, including doctor’s notes
- Other patient metadata (age, sex, co-morbidities, etc.)
This dynamic model evolves with the patient over time, ensuring healthcare providers always have the most up-to-date information to guide clinical decisions.
GenAI Evidence Engine
Starlight’s GenAI Evidence Engine leverages Amazon Bedrock and Sophic’s proprietary Knowledgebase to generate draft consult narratives for genomic and pharmacogenomic test results.
Providers can:
- Quickly produce evidence-based reports
- Review, edit, and finalize genomic, drug, disease, and clinical trial content in each patient’s Holistic Patient Model
- Accelerate the delivery of actionable insights to improve patient care
Clinical Trials Navigator
The Clinical Trials Navigator intelligently matches patients to the most appropriate clinical trials, using advanced AI reasoning and LLM (Large Language Model) capabilities from Amazon Bedrock, integrated with Neo4j’s graph database.
How it works:
- Starlight’s query engine leverages the Holistic Patient Model, including detailed genomic test results, patient metadata (age, sex, clinical notes), and other diagnostic data
- The system filters clinical trials based on patient-specific criteria: age, sex, diagnosed diseases, co-morbidities
- LLM-driven ranking surfaces trials that best match the patient profile, maximizing inclusion potential while minimizing exclusion factors
- Summaries of inclusion and exclusion criteria are automatically generated for each trial
- Additional information needed to fully evaluate whether the trial is appropriate for the patient, including trials that target the patient’s genomic profile and therapies that are different than previous therapies the patient has received, is included
- The resulting ranked trial options are displayed for easy clinical review
This process seamlessly integrates patient data with clinical trial databases, providing accurate trial matching with Neo4j graph technology and advanced natural language processing tools.
GenAI Intelligence
With GenAI Intelligence, users can interact with the Holistic Patient Model through an intuitive, natural language interface.
At any point while reviewing a patient’s model, providers can “ask questions” via prompts and receive accurate, conversational answers, powered by Amazon Bedrock Generative AI and Neo4j graph technology.
The system surfaces trusted knowledge networks from:
- Genomic variants
- Disease states
- FDA-approved drug labels
- Clinical trial registries
- Other verified medical data
Key benefits:
- Rapid access to trusted information across disparate data sources
- No hallucinations, only validated content
- A simple, user-friendly interface that helps providers “see in the dark” and discover new insights that may impact care
Powered by AWS & Neo4j
Sophic Starlight combines the advanced capabilities of Amazon Bedrock, Neo4j graph technology, and Sophic’s proprietary knowledgebase and AI model, delivering a uniquely powerful platform for advancing precision medicine.
Learn More
Interested in seeing how Sophic Starlight is transforming genomic test analysis?
Watch this on-demand webinar, hosted by CIO Online and featuring experts from AWS, Neo4j, and Sophic Alliance, to explore how the groundbreaking Starlight platform is advancing precision medicine.
For more information or to discuss how Starlight can support your organization, contact:
Patrick Blake
📞 508-564-0386
✉️ pat@sophicalliance.com
